4 research outputs found
Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19
- Author
- ?ivko Iris
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Nick
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Adhikari Sheetal
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Enezi Farhan
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderman Meera
- Aldo Bonizzoni Matteo
- Alegria Ana
- Alessandro Carà Gianmarco
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Almeshhedani Hasham
- AlQahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Al Amri Ali
- Al Qasim Eman
- Amatya Sameena
- Ambrosino Richard
- Anderson Thomas
- Andreae Mark
- Aneman Anders
- Angus Derek C.
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Aquino Maia
- Arabi Yaseen M.
- Arachchige Malka
- Aravindan Latha
- Arbane Gill
- Archambault Patrick
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Arnott Andrew
- Arora Anand
- Aryal Diptesh
- Asghar Adeeba
- Asif Namra
- Aspinwall Angelique
- Attokaran Antony
- Attwood Ben
- Au Carly
- Audry Mathilde
- Austin Karen
- Austin Pauline
- Auvet Adrien
- Avard Bronwyn
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- Azaiz Amine
- Azzaui Harun
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- Bagshaw Sean
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- Wright Kim
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- Xavier Kugan
- Yamagishi Yoshiaki
- Yamashita Chizuru
- Yang Yang
- Yarad Elizabeth
- Yates Bryan
- Yates David
- Yealy Donald
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zarychanski Ryan
- Zdanavidiene Ausra
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 11/04/2023
- Field of study
IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19.
Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19.
DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022).
INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days.
MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes.
RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively).
CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes.
TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570
Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data
- Author
- Aarnio K.
- Acosta Boris Raul
- Aegidius Karen
- Akutsu Tsugio
- Albiker Christian
- Alegiani Anna
- Alemseged F.
- Almendrote Miriam
- Alonso Angelika
- Althaus Katharina
- Althaus-Knaurer Katharina
- Amarenco Pierre
- Amiri Hemasse
- Anders Bettina
- Anderson C.
- Ang T.
- Aniculaesei Adriana
- Aoki Junya
- Appleton Jason
- Arakawa Shuji
- Archer M. L.
- Arenillas Juan
- Attia J.
- Back Christina
- Bailey P.
- Balabanski A.
- Barber A.
- Barber P. A.
- Bardutzky J. rgen
- Baronnet-Chauvet Flore
- Bathe-Peters Rouven
- Bayer-Karpinska Anna
- Becerra Juan L.
- Beck Christoph
- Belchí Guillamon Olga
- Bendszus Martin
- Benoit Amandine
- Berhoune Nadia
- Bernhardt J.
- Berrouschot J. rg
- Betensky Rebecca A.
- Bindila Daniela
- Birchenall Julia
- Bivard A.
- Blacker D.
- Bladin C. F.
- Bladin Christopher F.
- Blanc-Lasserre Karine
- Blanco Gonzales Miguel
- Bluhmki Erich
- Bobinger Tobias
- Bodechtel Ulf
- Bodiguel Eric
- Bojaryn Urszula
- Bonnet Louise
- Bouamra Benjamin
- Boulouis Gregoire
- Bourgeois Paul
- Boutitie Florent
- Bovi Paolo
- Breuer Lorenz
- Breynaert Ludovic
- Brodtmann A.
- Broughton David
- Brouns Raf
- Brugirard S. bastian
- Bruneel Bart
- Buggle Florian
- Bähr Christian
- Cadilhac D.
- Cakmak Serkan
- Calleja Ana
- Calvet David
- Campbell B. C. V.
- Campbell Bruce C. V.
- Carandang Raphael A.
- Carey L.
- Carrera David
- Celestino S.
- Chan L.
- Chang W. H.
- ChangI A.
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- Chen Hsin-Chieh
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- Chen W. H.
- Chen Y. Y.
- Cheng Bastian
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- Cheong E.
- Cheripelli Bharath
- Chiou Y. W.
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- Christensen Hanne
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- Edjali-Goujon Myriam
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- el Tawil Salwa
- Elhfnawy Ahmed
- Endres Matthias
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- Eschenfelder Christoph
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- Furui Eisuke
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- Gruber Franz
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- Gunreben Ignaz
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- Hacke Werner
- Haertig Florian
- Hallenbeck John
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- Höfner Elmar
- Ichijyo Masahiko
- Ide Toshihiro
- Igarashi Shuichi
- Iguchi Yasuyuki
- Ihara Masafumi
- Ikenouchi Hajime
- Inoue Manabu
- Inoue Tsuyoshi
- Ipsen Nils
- Isern Irina
- Ispierto Lourdes
- Itabashi Ryo
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- Iversen Helle
- Iwama Toru
- Jackson D.
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- Jimenez Marta
- Jungehülsing Jan
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- Kalladka Dheeraj
- Kallmünzer Bernd
- Kamiyama Kenji
- Kamiyoshi Shoko
- Kanai Haruka
- Kanematsu Yasuhisa
- Kanzawa Takao
- Kapeller Peter
- Kar Arindam
- Kasari O.
- Kase Carlos
- Kaste Markku
- Kellert Lars
- Kemmling André
- Kessler Christof
- Kessler Tobias
- Khan Usman
- Kimura Kazumi
- King J.
- Kitayama Jiro
- Kitazono Takanari
- Klein Matthias
- Kleinig T. J.
- Kleinig Timothy J.
- Kleinschnitz Christoph
- Klockziem Matti
- Knops Michael
- Koehler Luzie
- Koehrmann Martin
- Koga Masatoshi
- Kohlfürst Heinz
- Koivu M.
- Kolbe J.
- Kollmar Rainer
- Kondo Rei
- Kraft Peter
- Krause M.
- Krause Thomas
- Kristensen Bo
- Kröber Jan M.
- Kuan C. W.
- Kudo Kohsuke
- Kung W. L.
- Kurka Natalia
- Kusumi Masayoshi
- Kuwahara Ken
- Kyndt C.
- Köhrmann Martin
- Laage Rico
- Ladoux Alexandre
- Laloux Patrice
- Lamy Catherine
- Landrault Emmanuelle
- Latour Lawrence
- Latour Lawrence L.
- Lau C. L.
- Lauer Arne
- Lebely Claire
- Lee A.
- Lee C. Y.
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- Lees Kennedy
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- Leger Anne
- Legrand Laurence
- Lemmens Robin
- Lev Michael H.
- Levi C.
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- London Frederic
- Lopez-cancio Elena
- Lorenz Matthias
- Louw Stephen
- Lovelock Caroline
- Low E.
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- Lu C. H.
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- Lückl Janos
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- Madzar Dominik
- Mahadevan J.
- Majoie Charles
- Maqueda Vicky
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- Martinez Alicia
- Marzina Annika
- Mas Jean-Louis
- Matsumoto Shoji
- Matsuoka Hideki
- Maxwell V.
- McCoy R.
- McDonald A.
- McModie S.
- Mechthouff Laura
- Meden Per
- Meersman Guy
- Meier Julia
- Mellerio Charles
- Menn Oliver
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- Michalski Dominik
- Michels Peter
- Michelsen Lene
- Mihara Ban
- Mikulik Robert
- Millán Torne Monica
- Minematsu Kazuo
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- Mishra S.
- Mitchell P. J.
- Miteff F.
- Miura Ken
- Miwa Kaori
- Modrau Boris
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- Molina Carlos
- Molina Carlos A.
- Moore A.
- Morel Nathalie
- Moreton Fiona
- Morin Ludovic
- Morita Naomi
- Moulin Thierry
- Mouri Wataru
- Moynihan Barry
- Muddegowda Girish
- Mueller Anne K.
- Muir Keith
- Muir Keith W.
- Muir Keith W.
- Mulero Patricia
- Muller C.
- Mundiyanapurath Sibu
- Murata Kayo
- Mutzenbach Johannes
- Muzikansky Alona
- Männer Anika
- Møller Anette
- Nagakane Yoshinari
- Nagaraja Nandakumar
- Nagel Simon
- Naggara Oliver
- Nakase Taizen
- Nallasivan Arumugam
- Navalpotro Irene
- Nave Alexander H.
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- Neeb Lars
- Neugebauer Hermann
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- Oberndorfer Stefan
- Ohara Hiromi
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- Ohnishi Hideyuki
- Ohta Hajime
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- Ohtsuki Toshiho
- Ohyama Hideo
- Okada Takashi
- Okada Yasushi
- Opherk Christian
- Oppel Lorenz
- Oppenheim Catherine
- Orthgieß Johannes
- Osaki Masato
- Ostergaard Leif
- Oxley T. J.
- Paindeville Perrine
- Palomeras Ernest
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- Parsons M. W.
- Parsons Mark W.
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- Pedraza Salvador
- Peeters Andre
- Peeters Dirk
- Pellisé Anna
- Pelz Johann
- Peng G. S.
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- Perry Richard
- Pesavento L.
- Petraza Salvador
- Peysson Stéphane
- Pfeilschifter Waltraud
- Phan T.
- Pichler Alexander
- Pierskalla Alexandra
- Pledl Hans-Werner
- Poli Sven
- Pomrehn Katrin
- Poulsen Marika
- Prats Luis
- Presas Silvia
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- Puetz Volker
- Puig Alcántara Josep
- Puig Josep
- Purrucker Jan
- Pérez de la Ossa Natalia
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- Ramachandran Sankaranarayanan
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- Turine Gaetane
- Tyrell Pippa
- Tütüncü Serdar
- Ueda Toshihiro
- Uesaka Yoshikazu
- Uotani Mihoko
- Urabe Takao
- Ustrell Xavier
- Vadot Wilfried
- Vallat W.
- Vallet Anne-Evelyne
- Vallet Pauline
- van den Berg Lucie
- van den Berg Sophie
- van Eendenburg Cecile
- van Hooff Robbert-Jan
- van Sloten Isabelle
- Vanacker Peter
- Vancaester Evelien
- Vanderdonckt Patrick
- Vandermeeren Yves
- Vanhee Frederik
- Veltkamp Roland
- Vestergaard Karsten
- Viguier Alain
- Vilas Dolores
- Villringer Kersten
- Virta J.
- Voget Dieke
- von Kummer R. diger
- von Schrader J. rg
- von Weitzel Paul
- Wahlgren Nils
- Wang W. C.
- Wang Y. T.
- Warach Steven
- Warburton Elisabeth
- Wardlaw Joanna
- Watanabe Masao
- Waters M.
- Weber Claudia
- Weber J. rg
- Wegscheider Karl
- Wegscheider Mirko
- Weimar Christian
- Weinstich Karin
- Weir L.
- Weise Christopher
- Weise Gesa
- Wijeratne T.
- Willems Chris
- Williams C.
- Wilson W.
- Winder Klemens
- Wittayer Matthias
- Wolf Marc
- Wolf Martin
- Wolff Valerie
- Wollboldt Christian
- Wollenweber Frank
- Wong A. A.
- Wong K.
- Wouters Anke
- Wu Ona
- Wu T. Y.
- Wu Y. H.
- Yagita Yoshiki
- Yakushiji Yusuke
- Yalo Bertrand
- Yamamoto Haruko
- Yan B.
- Yang F. C.
- Yang Y. W.
- Yassi N.
- Yassi Nawaf
- Yasui Keizo
- Yeh H. L.
- Yeh J. H.
- Yeh S. J.
- Yen C. H.
- Yger Marion
- Yonehara Toshiro
- Yoo Albert J.
- Yoshimura Shinichi
- Yoshimura Sohei
- Younan Nadia
- Young D.
- Yperzeele Laetita
- Ysai C. L.
- Zand Ramin
- Zegarac Vesna
- Zeiner Pia
- Zhang W. W.
- Zhao H.
- Zhao L.
- Ziemann Ulf
- Zonneveld Thomas
- Zuber Mathieu
- Publication venue
- 'Elsevier BV'
- Publication date
- 14/11/2020
- Field of study
Background: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. Methods: We did a systematic review and meta-analysis of individual patient data for trials published before Sept 21, 2020. Randomised trials of intravenous alteplase versus standard of care or placebo in adults with stroke with unknown time of onset with perfusion-diffusion MRI, perfusion CT, or MRI with diffusion weighted imaging-fluid attenuated inversion recovery (DWI-FLAIR) mismatch were eligible. The primary outcome was favourable functional outcome (score of 0–1 on the modified Rankin Scale [mRS]) at 90 days indicating no disability using an unconditional mixed-effect logistic-regression model fitted to estimate the treatment effect. Secondary outcomes were mRS shift towards a better functional outcome and independent outcome (mRS 0–2) at 90 days. Safety outcomes included death, severe disability or death (mRS score 4–6), and symptomatic intracranial haemorrhage. This study is registered with PROSPERO, CRD42020166903. Findings: Of 249 identified abstracts, four trials met our eligibility criteria for inclusion: WAKE-UP, EXTEND, THAWS, and ECASS-4. The four trials provided individual patient data for 843 individuals, of whom 429 (51%) were assigned to alteplase and 414 (49%) to placebo or standard care. A favourable outcome occurred in 199 (47%) of 420 patients with alteplase and in 160 (39%) of 409 patients among controls (adjusted odds ratio [OR] 1·49 [95% CI 1·10–2·03]; p=0·011), with low heterogeneity across studies (I 2=27%). Alteplase was associated with a significant shift towards better functional outcome (adjusted common OR 1·38 [95% CI 1·05–1·80]; p=0·019), and a higher odds of independent outcome (adjusted OR 1·50 [1·06–2·12]; p=0·022). In the alteplase group, 90 (21%) patients were severely disabled or died (mRS score 4–6), compared with 102 (25%) patients in the control group (adjusted OR 0·76 [0·52–1·11]; p=0·15). 27 (6%) patients died in the alteplase group and 14 (3%) patients died among controls (adjusted OR 2·06 [1·03–4·09]; p=0·040). The prevalence of symptomatic intracranial haemorrhage was higher in the alteplase group than among controls (11 [3%] vs two [<1%], adjusted OR 5·58 [1·22–25·50]; p=0·024). Interpretation: In patients who have had a stroke with unknown time of onset with a DWI-FLAIR or perfusion mismatch, intravenous alteplase resulted in better functional outcome at 90 days than placebo or standard care. A net benefit was observed for all functional outcomes despite an increased risk of symptomatic intracranial haemorrhage. Although there were more deaths with alteplase than placebo, there were fewer cases of severe disability or death. Funding: None
Effect of Antiplatelet Therapy on Survival and Organ Support–Free Days in Critically Ill Patients With COVID-19
- Author
- Abbass Hakam
- Abdeladim Lilia
- Abdelhady Hesham
- Abdelkharim Hussam
- Abdelrazik Marwa
- Abdi Zakee
- Abdukahil Sheryl Ann
- Abel Lynn
- Abraham Jacinta
- Abrahamson Gail
- Abusamra Yousuf
- Aceto Romina
- Adams Peter
- Adebambo Olumide
- Adhikari Neill
- Affleck Julia
- Agha Gloria
- Aghemo Alessio
- Agno Ronan
- Aguilar-Dano April
- Ahmad Norfaizan
- Ain Quratul
- Ainscough Kate
- Ainsworth James
- Aitken Lindianne
- Akamp Ceren
- Al Amri Ali
- Al Enezi Farhan
- Al Qasim Eman
- Al-Bassam Wisam
- Al-Beidh Farah
- Albert Martin
- Albrett Jonathan
- Alderink Bashar
- Alderman Meera
- Alegria Ana
- Alexander Brian
- Alexander Peter
- Alfonso Jordan
- Ali Farisha
- Ali Maryam
- Ali Murtaza
- Allam Hayat
- Allen Barbara
- Allen Louise
- Allibone Suzanne
- Alqahtani Samah
- Alswaidan Lolowa
- Altomy Mohammed
- Amatya Sameena
- Ambrosino Richard
- Anders Jeanette
- Anderson Thomas
- Andreae Mark
- Andric Zdravko
- Angus Derek
- Anjum Aisha
- Ankert Juliane
- Annane Djillali
- Anne-Laure Fedou
- Anstey Matthew
- Antcliffe David
- Anthony Alpha
- Antoine Marchalot
- Antoine Pierre
- Antoine Studer
- Anumakonda Vikram
- Aparicio Christelle
- Apte Yogesh
- Arabi Yaseen
- Arachchige Malka
- Arbane Gill
- Archer Simon
- Aref Noah
- Arias Ana-Marie
- Arias Sonia
- Arishi Hatim
- Arnold Donald
- Arnold John
- Aryal Diptesh
- Asif Namra
- Aspinwall Angelique
- Attanayaka Udara
- Attokaran Antony
- Attwood Ben
- Au Carly
- Austin Karen
- Austin Pauline
- Avard Bronwyn
- Awan Sidra
- Azaiz Amine
- Azergui Nora
- Azzaui Harun
- Babel Jakša
- Babu Suresh
- Bacon Gina
- Badalamenti Salvatore
- Badie Julio
- Bagavathy Kavitha
- Bagot Catherine
- Bagshaw Sean
- Baig Nadia
- Baikady Ravishankar
- Baillie Kenneth
- Bain William
- Baker Evelyn
- Bakthavatsalam Dhanalakshmi
- Balaie Morteza
- Bamford Amy
- Bamford Peter
- Banach Dorota
- Bannard-Smith Jonathan
- Barbash Ian
- Barbazza Leanne
- Barber Russell
- Barbier François
- Barge Deborah
- Bari Sara
- Bariola Ryan
- Barker Gareth
- Barnes Nicky
- Baron Rebecca
- Barreau Amelie
- Bart Robert
- Bartholdy Roland
- Bartley Shauna
- Barton David
- Barton Frances
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- Tuckwell Caroline
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- Turgeon Alexis
- Turki Salah
- Turner Anne
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- Turns Margaret
- Tv Bharath
- Udayanga Ishara
- Uddin Ruzena
- Udy Andrew
- Umrani Zulfiqar
- Uriel Alison
- Ustianowski Andrew
- Uyeki Tim
- Vaara Suvi
- Vaduganathan Muthiah
- Vahtera Annukka
- Vale Cassandra
- Valentine Eliza
- Vamplew Luke
- van Bentum-Puijk Wilma
- van Beurden Marloes
- van Bree Sjoerd
- van de Veerdonk Frank
- van den Berg Lettie
- van den Oever Huub
- van der Eng Hetty
- van der Heyden Kymbalee
- van der Kraan-Donker Annemarie
- van Gulik Laura
- van Kimmenade Roland
- van Nieuwkoop Kees
- van Oosten Nienke
- van Opdorp Marjolein
- van Vonderen Marit
- van Zanten Arthur
- van Zuylen Tamara
- Vanjak Christian
- Vanmali Piyush
- Vargas Jr. Jesus
- Varghese Siby
- Vautier Sarah
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- Veenith Tonny
- Venkatesh Bala
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- Vermeiren Daisy
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- Vertue Mark
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- Viehman Alex
- Vieillard-Baron Antoine
- Vignesh C
- Vincent Rachel
- Virdee Satwinder
- Visser Yorik
- Vita Tina
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- Voicu Sebastian
- Voigt Ingo
- Voiriot Guillaume
- Voza Antonio
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- Vuylsteke Alain
- Wagh Atul
- Wahl Nadine
- Waite Alicia
- Walden Andrew
- Walker Gena
- Walker Rachel
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- Walsh Tim
- Walsham James
- Wang Shu
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- Ward Kathryn
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- Warnock Majella
- Watchorn Olivia
- Waters Abby
- Waterson Sharon
- Watkins Claire
- Watpool Irene
- Watts Angela
- Waugh Victoria
- Webb Steve
- Weber Lisa
- Weerasinghe Thanuja
- Weismann Dirk
- Weiss Daniel
- Weissman Alexandra
- Wells Colin
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- Westlake Samantha
- Wetherill Bill
- Wetzold Richard
- Whileman Amanda
- Whitbread Jennifer
- White Alison
- White Hayden
- White Ian
- White Katie
- Whitehead Christina
- Whitehouse Tony
- Wibrow Bradley
- Wigbers Jeanette
- Wilby Elizabeth
- Wilcox Elizabeth
- Wilcox Louise
- Wild Helen
- Wild Laura
- Wilding Laura
- Wiles Matt
- Wiley Daisy
- Wilhelmsen Elva
- Wilkinson Dean
- Willams Felicity
- Williams Alexandra
- Williams Angharad
- Williams Anna
- Williams Erin
- Williams Gemma
- Williams Karen
- Williams Patricia
- Williams Tony
- Williams Virginie
- Willis Joanna
- Willson Jayne
- Wilson Anna
- Wilson Craig
- Wilson Maggie
- Winters James
- Winters Lauren
- Wise Matt
- Wiseman Sophie
- Wisniewski Mary
- Wittenberg Wendy
- Wnuk Chris
- Woelke Amy
- Wong Helen
- Wong Onyee
- Wood Erica
- Wood Hannah
- Wood Tracy
- Woods Jane
- Woods Lindsey
- Worner Ruth
- Wren Jess
- Wren Lynn
- Wrey Brown Caroline
- Wright Chris
- Wunderley Renee
- Wyatt Rachel
- Wylie Katharine
- Xavier Kugan
- Yang Yang
- Yarad Elizabeth
- Yates David
- Yealy Donald
- Young Chelsea
- Young Ian
- Young Meredith
- Young Paul
- Youngstein Taryn
- Yu Haili
- Yusuff Hakeem
- Zaharia Mihaela
- Zaidi Abbas
- Zaki Ahmed
- Zaman Mohsin
- Zammit Claire
- Zapalac Marija
- Zarychanski Ryan
- Zhao Xiao
- Zinzoni Vanessa
- Zitter Letizia
- Zouita Louisa
- Đimoti Renata
- Publication venue
- American Medical Association
- Publication date
- 05/04/2022
- Field of study
International audienc
Analysis of Outcomes in Ischemic vs Nonischemic Cardiomyopathy in Patients With Atrial Fibrillation A Report From the GARFIELD-AF Registry
- Author
- A'Court Christine
- Abdel-Qader Muwafeg
- Abe Masahiko
- Abe Masatake
- Abe Mitsunori
- Abe Sumihisa
- Abe Yukihiko
- Abhayaratna Walter
- Accogli Michele
- Adachi Susumu
- Adachi Toru
- Adak Dhriti
- Adam Matthew
- Adriaansen Henk
- Aegerter Emanuel
- Ageta Masato
- Aggarwala Anil
- Agnelli Giancarlo
- AgnieszkaMetzgier-Gumiela AgnieszkaMetzgier-Gumiela
- Ahlmark Hakan
- Ahmad Kamran
- Ahmad Shahid
- Ahmed Fayzal
- Ahn Jung Joo
- Akers Lori
- Akiyama Masahiro
- Al Mahmeed Wael
- Al-Khalili Faris
- Alberts Mark
- Alborough Elizabeth
- Aldegather Jehad
- Aleksandrova Elena
- Alexandre Almeida Carlos
- Ali Amar
- Ali Gholam
- Alia Pilar Montero
- Allasia Bartolomeo
- Alonso Carmela
- Alonso Concepcion
- Altun Armagan
- Alunni Massimo
- Alvarez Garcia Pere
- Alvarez Douglas
- Alvarez Miguel
- Alzogaray Maria Fernanda
- Amarenco Pierre
- Amaro Marisol
- Ambicka Monika
- Ambrosino Pasquale
- Ambrosio Giuseppe
- Amin Joseph
- Amrhein Diana
- Amstutz Daniela
- An Hae Jung
- Andere Natalia
- Andersson Agneta
- Andersson Lisbeth
- Ando Hiroshi
- Ando Shinichi
- Andrzejewski Dariusz
- Angaran Paul
- Ansoult Nadege
- Antonova Petra
- Antonsen Hege
- Aoki Kenji
- Aoyama Takuma
- Appleby Nigel
- Appleby Nigel
- Aracil Villar Joaquin
- Arai Hidekazu
- Araminowicz Joanna
- Aras Funda
- Arcocha Torres Maria Fe
- Argena Antonio
- Arima Shinichi
- Armangau Pauline
- Arstall Margaret
- Asafu-Adjaye Nana
- Asano Hiroshi
- Asano Taku
- Ashraf M. Javed
- Assagay Maharajh S.
- Assouline Serge
- Astridge Penny
- Atar Dan
- Atar Dan
- Ausen Karin
- Austria Aileen
- Aves Theresa
- Avinc Gamze
- Avinc Gamze
- Avinc Gamze
- Axthelm Christoph
- Ayar Ozge
- Aydinlar Ali
- Ayres Bronte
- Azakami Shiro
- Aziz Michael
- Azuma Junya
- Baba Takao
- Babjakova Zuzana
- Babyesiza Adyeri
- Bae Sang Cheol
- Baek Ae Lee
- Baglioni Gregorio
- Bai Chunlin
- Baksh Farisha
- Balaraju Swathi
- Ball Kelly
- Bamungpong Panthipa
- Banfi Elena
- Barbarash Olga
- Barbeira Pablo Saleta
- Barkowski Timothy
- Barnes Dylan
- Barnes Dylan
- Baron Esquivias Gonzalo
- Barraquer Feu Edelmira
- Barreau Angeline
- Barreda Maria
- Barretto Antonio Carlos Pereira
- Barrow Susan
- Barry Lisa
- Bartkowiak Radoslaw
- Bartlett Melialoha
- Bartnik Jerzy
- Basiak Marcin
- Basily Wagdy
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bassand Jean-Pierre
- Bastani Lisa
- Baszak Jacek
- Batalov Roman
- Batlle Javier
- Batta Claire
- Batta Claire
- Baumbach Sylvia
- Baumgartner Philipp
- Baweja Paramdeep
- Bayat Junaid
- Beattie Andre
- Becerra Munoz Victor
- Begum Haseena
- Bekieszczuk Ewa
- Belenkova Yulia
- Belenky Dmitry
- Bengtsberg Daniel
- Bennett James
- Berardi Mario
- Berg-Johansen Berg-Johansen
- Berge Eivind
- Berge Trude
- Berit Anne
- Berman Sofia Graciela
- Bernat Lukasz
- Berneau Jean-Baptiste
- Best Peggy
- Beton Osman
- Betsuyaku Tetsuo
- Beveridge Rosemary
- Bezrodna Larysa
- Bhargava Kartikeya
- Biagioli Viviana
- Bianchi Alfredo
- Biedrzycka Malgorzata
- Biedrzycka Malgorzata
- Biedrzycki Lukasz
- Biernacka Anita
- Bigcanoe Julie
- Bignell Nanci
- Bilas Roman
- Bilecen Sinan
- Billger Annelie
- Bindig Hans-Walter
- Binnekamp Maurits
- Bird Nigel
- Bireciklioglu Mustafa Fehmi
- Birhan MEHMET BİRHAN
- Bitakova Fatima
- Black Andrew
- Blenkhorn Adam
- Blinkova Marina
- Blombery Peter
- Blumberg Edwin
- Bockova Lucie
- Boda Zoltan
- Boehme Stefanie
- Boen Rigmor
- Boersma Misannia
- Boggian Giulio
- Bonet Jorge
- Bongaerts Maarten
- Bongiorni Maria Grazia
- Bonin Kerstin
- Bonkowski Grzegorz
- Bonner Michelle
- Bonnetain Anne
- Boon Jannie
- Boonyapisit Warangkana
- Boos Laura
- Booysen Maria
- Borjesson Ulf
- Borras Ana Domenech
- Boshoff Cecilia
- Bosman Femmy
- Bosschaert Mike
- Bossolasco Pierdomenico
- Botha Margo
- Bottarelli Maria Luisa
- Bouzamayor Maria Belen Lage
- Bowen-Simpkins Emma
- Bowers Suzanne
- Boys Janice
- Bradshaw Colin
- Braham Simon
- Brauer Gunter
- Bray Bryan
- Breakwell Lynn
- Bremmelgaard Arne
- Breschi Marco
- Breukel Laura
- Briceno Hinojo Ana
- Brimley Jennifer
- Broad Oulton
- Brodmann Marianne
- Bronisz Marek
- Broton Elzbieta
- Brotons Cuixart Carles
- Browne Debbie
- Bruegger Jasmine
- Brugnaux Jean Philippe
- Bruin Sandra
- Brusorio Stefania
- Bruun Michael
- Bruun Michael
- Brzustowska Malgorzata
- Buckley Elizabeth
- Buiks Paul
- Bulla Claudio
- Bultas Jan
- Bunyapipat Thanita
- Burdeina Liudmyla
- Burke Elizabeth
- Burns Stephen
- Busch Florian
- Butter Keith
- Cabrera Ramos Mercedes
- Cabrini Romina
- Caimi Teresa Maria
- Calcagnoli Francesca
- Cameron Alex
- Camm A. John
- Camm A. John
- Camm A. John
- Camm A. John
- Campagna Giuseppe
- Campo Moreno Mariela
- Campo Monica
- Cancho Corchado Gema
- Cannon Claire
- Canosa Roddy
- Canova Michaela
- Cao Shiping
- Cap Austl
- Cappelli Roberto
- Capucci Alessandro
- Carlton Lesley
- Carpenedo Monica
- Carroll Lisa
- Carroll Patrick
- Cartasegna Luis Rodolfo
- Cartwright Simon
- Casanova Gil Miguel
- Casassus Frederic
- Caspar Andreas
- Cassidy Doran
- Cassimjee Soraya
- Castillo Orive Miguel
- Castro Fernandez Daniel
- Catanchin Andrei
- Cebron Jean-Pierre
- Cervellione Kelly
- Cha James
- Cha Tae-Joon
- Chabanna Olena
- Chaiyapong Thanawan
- Chami Charmaine
- Chandwani Prakash
- Chattranukulchai Pairoj
- Chauhan Kuldeep
- Chauhan Naresh
- Cheewatanakornkul Sirichai
- Chemin Frederic
- Chen Jiyan
- Chen Kangning
- Chen Xiao
- Cheryl Laurie Ferleyko
- Cheung Stephen
- Chi Andwoo Jin
- Chiba Kei
- Chibana Hidetoshi
- Ching Chi Keong
- Chizhov Petr
- Chlumsky Jaromir
- Chmielowski Artur
- Cho Amie
- Cho Jeong-Gwan
- Cho Myeong-Chan
- Choi Dong Ju
- Choi Eun A.
- Choi Eun Hee
- Choi Hee Kyung
- Choi Hee Suk
- Chojnowski Przemyslaw
- Choudhary Fiaz
- Choudhary Ulka
- Chowan Hasan
- Christie Heather
- Christoph Marian
- Chugunnaya Svetlana
- Ciabatta Carlo
- Cichomski Rafal
- Cieslak Karol
- Cieszynska Alina
- Ciliberti Giuseppe
- Cimmino Giovanni
- Citykliniken Capio
- Clark M.
- Clarke Bonnie
- Claussen Hege
- Cleveland Tracy
- Cloak Cloak
- Coates Richard
- Coates Steven
- Coates Steven
- Colomes Anne
- Colquhoun David
- Colquhoun David
- Conn Paul
- Connolly Stuart J.
- Conway Gladys
- Cooke Philip
- Cools Frank
- Cooper Krystine
- Corbalan Ramon
- Corbalan Ramon
- Cordoba Mateo
- Corrihons Estelle
- Costa Pinto Joana
- Costello Ben
- Couleru Josette
- Coulshed David
- Coulson DrWarwick
- Coutu Benoit
- Cresp Damien
- Crisby Milita
- Cristina Leone Maria
- Croucher Alexandra
- Curyllo Bartosz
- Cymerman Krzysztof
- Czamara Marcin
- D'Agostini Erika
- D'Avino Maria
- Danielsen Mark
- Danilowicz-Szymanowicz Ludmila
- Daniuk Inna
- Danse Ingrid
- DArienzo Carmela
- Darius Harald
- Darius Harald
- Dastychova Lenka
- Date Haruhiko
- Davids Aziza
- Davies Divin
- Davies Emyr
- Davies Richard
- Davis Kent
- Dawood Dawood
- De Blasio Angelo
- De Cristofaro Raimondo
- De Graaf Judith
- de Meyer Lorinda
- Deacon Melanie
- Debordes Mirjam
- Debrunner Johann
- Debruxelles Sabrina
- Decarsin Nathalie
- Dedek Vratislav
- Dehghani Payam
- Delafontaine Patrice
- Delarche Nicolas
- Demir Mesut
- Denis Isabelle
- DePauw Jill
- Deshpande Bhakti
- Dhakrao Priyanka
- Dhillon Ripple
- Di Ancona Torrette
- Di Minno Giovanni
- Diaz Lopez Carlos Maria
- Dichristin Uta
- Diederichs Roelof
- Diercks Deborah
- Dimitri Hany
- Dixon Sue
- Dobson Simon
- Dohovits Emese
- Doiuchi Junji
- Dolman Marilyn
- Domanska Ewa
- Dominguez Helena
- Dominguez Helena
- Dominguez Ingrid
- Dooldeniya Chaminda
- Dorottya Kanizsai
- Dorsch Wilfried
- Douglas Kevin
- Douglass Shannen
- Drapkina Oksana
- Drasnar Tomas
- Dresser George
- Drexel Heinz
- Drown Jane
- Dshabrailov Janna
- du Preez Miranda
- Duff-Coots Margie
- Dumikyan Anait
- Dwivedi Pratik
- Dwyer Nathan
- Dybala Tomasz
- Dzeletovic Susanna
- Earath Manoj
- Ebert Hans-Holger
- Ebner Karl-Martin
- Eccleston David
- Eden Jane
- Eder Wolfgang
- Edin Anton
- Efe Jana
- Egilsson Arnor
- Egorova Liudmila
- Egyutt Mihaly
- Eikelboom John
- Eikelboom John
- Eisleben Lutherstadt
- Eissing Volker
- Ekstrand Ann-Britt
- El-Aziz Ahmed Abd
- El-Etreby Adel
- Elise Guillermet
- Elkhadem Magdi
- Ellervik Christina
- Ellis Tania
- Elmersson Micael
- Elorriaga Madariaga Ane
- Emelife Samuel
- Emura Yoko
- Endo Masato
- Engdahl Johan
- Engelbrecht Johannes
- Engelthaler Gabriella
- Epelde Gonzalo Francisco
- Erdle Werner
- Erga Knut
- Ericsson Marianne
- Ersanli Murat
- Eskandari Mehdi
- Eslick Renee
- Espallargas Anna
- Estifanos Salah
- Eto Takuma
- Evans Lorlie
- Evans Paul
- Evans Phil
- Ewald Gregory
- Ewert Alayna
- Fairhead Sue
- Fanelli Raffaele
- Faron Andwojciech
- Farquhar Donald
- Fattore Luciano
- Fearon Ann
- Fedele Marta
- Fedorowsky Alain
- Feil Jusztina
- Felekoglu Mehmet Ali
- Felpel Susan
- Femiano Claudio
- Feng Shuai
- Feola Mauro
- Ferdinand Keith
- Ferenczi Judit
- Ferkl Richard
- Fernandez Escobar Esther
- Ferreira-Jardim Antonio
- Ferreira-Jardim Antonio
- Ferrer Ana
- Ferrini Piera Maria
- Fetahovic Taufik
- Fielder Debbie
- Figura-Chmielewska Monika
- Figura-Chmielewska Monika
- Fikry Sameh
- Fikry Sameh
- Finlaison Judy Anne
- Fitzmaurice David
- Fitzmaurice David A.
- Fitzmaurice David A.
- Fitzpatrick Michael
- Fleck Anja
- Fleury Julie
- Flint Kerstin
- Floegel Hildegard
- Floren Karin
- Flynn Ann
- Foechterle Johannes
- Foechterle Johannes
- Fontanillas Maria Teixido
- Foo David
- Fooks Tim
- Foppa Luciano
- Forcignano Fulvio
- Forgo Veronika
- Forshaw Karen
- Fournier Denise
- Fox Beverley
- Fox Keith A. A.
- Fox Robin
- Frankiewicz Anna
- Franklin Simon
- French John
- Frick Marcel
- Fritella Roberta
- Frittella Roberta
- Fudo Tetsuro
- Fujii Masako
- Fujii Yuichi
- Fujiki Rei
- Fujimoto Shunichi
- Fujisawa Akinori
- Fujisawa Yasuaki
- Fujito Tsuneo
- Fujiura Yoshihisa
- Fujiura Yoshitake
- Fukuda Tsuyoshi
- Funda Balci
- Furukawa Nobufusa
- Furukawa Yoshiyuki
- Furumoto Wataru
- Fushtey Ivan
- Gadzinski Andwaldemar
- Galinier Michel
- Galloway Sophia
- Garcia Bermudez Miriam
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- Rosa Senan Maria
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- Rosenberg Karina
- Rosenqvist Marten
- Rosolin Nathalie
- Ross Andrew
- Rossovskaya Maria
- Rostoff Pawel
- Rostoff Pawel
- Roszczyk Nikolina
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- Ruiter J. H.
- Rupka Dennis
- Rusicka-Piekarz Teresa
- Ruszkowski Piotr
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- Ryu DongRyeol
- Saalfeld Rose
- Sadhu Nehal
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- Safodien Shireen
- Saga Ellen
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- Saito Tsutomu
- Sakamoto Norihiko
- Sakamoto Yasuhide
- Salem Hanan
- Salie Mishka
- Salomone Enrico
- Salomone Luisa
- Salvadores Juan
- Sambadaro Gustavo Alberto
- Samejima Yasuko
- Sami Nevein
- Samir Sameh
- Samodzielny Samodzielny
- Samuelsson Jessika
- Sanchez Calderon Pablo
- Sanchez Mendez Luisa
- Sanchez Parra Stela
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- Sanchez Parra Stela
- Sanchez Didier
- Sanchez Stela
- Sandow Petra
- Sanghera Tirath
- Sanit Kanchana
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- Sanno Kazuhisa
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- Scarone Cinzia
- Schaefer Benjamin
- Schaefer Thomas
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- Schmidt Kerstin
- Schoen Steffen
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- Sharp Helen
- Shawand Paula
- Shayesteh Mina
- Shekhar Amritanshu
- Shepherd Diane
- Shewring John
- Shibata Nitaro
- Shibuya Mitsuhiro
- Shiga Yuhei
- Shiga Yukio
- Shigekiyo Masahito
- Shiina Yumi
- Shim Jaemin
- Shimono Hisashi
- Shindo Takashi
- Shinohara Hisanori
- Shinohe Rikiya
- Shirai Takeaki
- Shiraiwa Toshihiko
- Shirakawa Kazuyuki
- Shoemaker Jay
- Short Stephanie
- Shrestha Prakriti
- Shudo Hiroshi
- Shumakov Oleksandr
- Shutemova Elena
- Sibon Igor
- Siebert Heidi
- Sierra Norberto
- Sierra Norberto
- Sierra Norberto
- Sievers Britta
- Sim JiHyun
- Simmons Phil
- Simon Valero Carmen
- Simon Sylvia
- Simonsen Peter
- Sindilar Ana Maria
- Singh Bhuwanendu
- Singh Carol
- Singhal Swati
- Singleton Cameron
- Sinha Bijoy
- Sinitsina Olga
- Sirichai Ratchanee
- Siriwattana Khanchai
- Sirnes Per Anton
- Skalska Jolanta
- Skein Annalie
- Skjelvan Gunnar
- Skoglund Kristina
- Skonieczny Grzegorz
- Smichura Monika
- Smith Kim
- Smith Leonie
- Smith R.
- Snell Linda
- Sobhy Michael
- Sobhy Mohamed
- Sobolev Russia Konstantin
- Sohn Young Mi
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- Solgaard Jorgen
- Soliman Ahmed
- Soma Akira
- Sommer Stefan
- Son Andwon Sook
- Son Yun Suk
- Song Changjie
- Sonoda Ryuji
- Sora Trinita
- Sorribes Lopez Josep
- Sottilota Gianluca
- Spacek Rudolf
- Spearson Sandrine
- Speshilova Svetlana
- Spinar Jindrich
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- Stapelberg Anna-Marie
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- Steden Kirsten
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- Stjernberg Mari
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- Tybura Sebastian
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- Wakeling John
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- Yamamoto Kiichiro
- Yamamoto Kunihiko
- Yamamoto Taku
- Yamasawa Masanori
- Yamaura Makoto
- Yamazoe Masahiro
- Yang Jingshan
- Yang Lingli
- Yang Zhiming
- Yawila Suree
- Yildirim Rifat
- Yilmaz Faruk
- Yilmaz Ozcan
- Yokota Naoto
- Yokoyama Yasuhiro
- Yoon Eunji
- Yoon Jung Han
- Yoshida Keiki
- Yoshida Tetsuro
- Yoshida Tomohiro
- Yoshida Tomoki
- Yoshimura Akira
- Yoshizawa Naoto
- Yu HyunJu
- Yu Ting
- Yusuf Huma
- Yuyang Tan
- Zaatout Eman
- Zaitsu Ryuji
- Zak Jan
- Zakutynska-Kowalczyk Karolina
- Zaluska Roman
- Zaman Kashif
- Zateyshchikov Dmitry
- Zauzig Heinz-Dieter
- Zdrowotnej Zespol Opieki
- Zecca Cinzia
- Zemlianskaia Oksana
- Zhai Hong
- Zhan Qiong
- Zhang Guoshan
- Zhang Huaiqin
- Zhang Ran
- Zhang Yi
- Zhao Yusheng
- Zhuravleva Evgeniya
- Zidek Milan
- Zidkova Eva
- Zika Jiri
- Zillo Mariana
- Zimmett Leon
- Zimny Hans-Hermann
- Zincke Stephanie
- Zinka Elzbieta
- Zinka Elzbieta
- Zotova Irina
- Zubeeva Galina
- Zuber Mathieu
- Zutz Stefan
- Zwenkau Schwarz
- Zyczynska Malgorzata
- Publication venue
- 'American Medical Association (AMA)'
- Publication date
- 01/06/2019
- Field of study
IMPORTANCE Congestive heart failure (CHF) is commonly associated with nonvalvular atrial fibrillation (AF), and their combination may affect treatment strategies and outcomes